THE EFFECT OF ANTIHISTAMINE PREPARATIONS ON THE DEVELOPMENT OF SOME EARLY RAY DISTURBANCES

Journal Article · Mon Jun 01 04:00:00 EDT 1959 · Doklady Akad. Nauk S.S.S.R.

OSTI ID:4235225

Gromakovskaya, M M; Krichevskaya, E I; Rapoport, S Ya

Studies of the effects of antihistamine preparations on free histamine levels and on histaminopexic ability of animal tissue showed that the preparations reduce the radiation effects by lowering the free histamine level of the skin. The effects of antihistamine drugs on the histo-hematic barrier penetrability in irradiated animals studied with P/sup 32/ indicator injected (4 mu Cu) immediately following irradiation are tabulated. The results indicate that the antihistaminic drugs, injected 15 to 20 min before exposure, prevent the changes in histo-hematic barrier penetrability in liver, kidneys, and brain. The data show that antihistamine drugs administered prior to irradiation protects the animal from the increase of free histamine level, protects the histo-hematic barrier penetrability against radiation effects, prevents changes in autonomic nervous system functions, and relaxes early radiation injuries to bone marrow. (R.V.J.)

• Research Organization: Inst. of Biological Physics, Academy of Sciences, U.S.S.R.
• NSA Number: NSA-13-017687
• OSTI ID: 4235225
• Journal Information: Doklady Akad. Nauk S.S.S.R., Journal Name: Doklady Akad. Nauk S.S.S.R. Vol. Vol: 126
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AMINES
ANIMALS
ANTIHISTAMINICS
BIOLOGY AND MEDICINE
BLOOD
BONE MARROW
BRAIN
DIFFUSION
DRUGS
HISTAMINE
IRRADIATION
KIDNEYS
LIVER
NERVOUS SYSTEM
PHOSPHORUS 32
QUANTITY RATIO
RADIATION EFFECTS
RADIATION PROTECTION
SKIN
TABLES
TISSUES
TRACER TECHNIQUES
VARIATIONS