METHOD FOR PREPARING NORMORPHINE
An improved method is presented for producing normorphine from morphine. Morphine as the starting material is acetylated by treatment with acetylating agents to produce di-acetyl morphine (heroin). The acetylated compound is reacted with cyanating agents to produce di-acetyl-cyanonormorphine (cyanonorheroin). The di-acetyl-cyanonormorphine compound is then treated in accordance with the improved hydrolysis reactions of the present invention in which concentrated hydrochloric acid is employed for a limited time period to hydrolyze the acetyl group therefrom forming cyanonormorphine. Subsequently, the reaction mixture is diluted and hydrolysis of the cyano groups from the cyanonormorphine is effected with a longer contact time with dilute hydrochloric acid thereby producing normorphine. A high over-all conversion and production of a high purity product which may be radioactlvely labeled, if desired, is obtained by operation of the process.
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-13-022049
- Assignee:
- U.S. Atomic Energy Commission
- Patent Number(s):
- US 2890221
- OSTI ID:
- 4229640
- Country of Publication:
- United States
- Language:
- English
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