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THE RELATIVE BIOLOGICAL EFFICIENCY OF SINGLE DOSES OF FAST NEUTRONS AND GAMMA-RAYS ON VICIA FABA ROOTS AND THE EFFECT OF OXYGEN. III. MITOTIC DELAY

Journal Article · · Intern. J. Radiation Biol.
OSTI ID:4221286
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The efficiency of approximately 3 Mev fast neutrons and cobalt-60 gamma rays in inducing mitotic delay in the primary roottip meristematic cells of Vicia faba has been studied. Fast-neutron doses of 2.02, 4.95, and 9.94 rads given under aerated and anoxic conditions, and gamma-ray doses of 46 and 114 rads given under conditions of aeration were used. The results show that there is no qualitative difference between neutron- and gamma-ray-induced mitotic delay, but marked quantitative differences were observed. The relative biological efficiency of fast neutrons to gamma-rays was about 10: 1, a value comparable to those obtained for inhibition of root growth and the production of micro-nuclei. The presence or absence of oxygen had little influence on the amount of mitotic delay induced by a given dose of neutron radiation. This oxygen enhancemeut factor of 1 for neutrons is in marked contrast to the oxygen factor of 2 found for mitotic delay induced by gamma-radiation. The factors for both the radiations appear to be a little smaller for this effect than for inhibition of root growth and for chromosome damage. The radiobiological implications of the values of rbe and oxygen factor are discussed. In spite of the simliarity of these factors for chromosome damage and mitotic delay, it is concluded that these effects do not stem from the same cellular lesion. (auth)
Research Organization:
Medical Research Council Radiobiological Research Unit, Harwell, Berks, Eng.
NSA Number:
NSA-14-002323
OSTI ID:
4221286
Journal Information:
Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 1
Country of Publication:
Country unknown/Code not available
Language:
English

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Related Subjects

AIR
BIOLOGY AND MEDICINE
CHROMOSOMES
COBALT 60
CYTOLOGY
FAST NEUTRONS
GAMMA RADIATION
MITOSIS
OXYGEN
PLANTS
RADIATION DOSES
RADIATION INJURIES
RADIOBIOLOGY
RADIOSENSITIVITY
RBE
ROOTS
VICIA
VICIA FABA