LIVER LIPID RESPONSE TO INTRAVENOUS RARE EARTHS IN RATS

Journal Article · Thu Oct 01 04:00:00 EDT 1959 · J. Lipid Research

OSTI ID:4202397

Snyder, F; Cress, E A; Kyker, G C

Intravenous injection of rare earths with low atomic numbers produces fatty infiltration in the liver of rats. This infiltration is maximal 48 hours later and is characterized by an increase in neutral fat esters. Total cholesterol and phospholipids of the liver in cerium-treated rats were similar to those of control livers. Cerium was found to be effective in producing extremely high levels of liver fat in female rats of several strains tested. Male rats treated in the same way did not exhibit the consistent response or the high liver- lipid levels that were seen in the females. After the castration of male rats, their response resembled that of females. Testosterone caused a significant reduction in the fatty infiltration induced by cerium in both intact and ovariectomized females. Hypophysectomy prevented fatty livers in both females and males, whereas adrenalectomy did so only in males. Choline and methionine bad no protective effect against cerium. Tracer experiments involving cerium-144 demonstrated that most of the radioactivity appeared in the acid-soluble fraction of the liver and that the lipid fraction contained essentially no tracer. (auth)

• Research Organization: Oak Ridge Inst. of Nuclear Studies, Tenn.
• NSA Number: NSA-14-005005
• OSTI ID: 4202397
• Journal Information: J. Lipid Research, Journal Name: J. Lipid Research Vol. Vol: 1
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADRENAL GLANDS
AMINO ACIDS
BIOLOGY AND MEDICINE
CERIUM
CERIUM 144
CHOLESTEROL
CHOLINE
CONTROL
DRUGS
ESTERS
GLANDS
GONADS
HORMONES
LIPIDS
LIVER
METHIONINE
ORGANIC ACIDS
PHOSPHOLIPIDS
PITUITARY GLAND
QUANTITY RATIO
RADIATION PROTECTION
RADIOACTIVITY
RARE EARTHS
RATS
SEX
SOLUBILITY
SURGERY
TESTING
TESTOSTERONE
TRACER TECHNIQUES
VITAMIN B GROUP
VITAMINS