RESEARCH ON "LOCALIZED RADIO-LESIONS." III. BLOOD VESSEL CHANGES FOLLOWING LOCAL IRRADIATION OF THE BRAIN WITH HIGH ENERGY PROTONS. Technical Report No. 1, Appendix 5
The cerebral cortex and thalaimus in the brain ef the rat were locally irradiated with a narrow beam of high energy protons. The developing radiolesion was studied with attention paid particularly to changes in capillary function. Semiquantitative comparison between effects at different times after irradiation with different doses in the region l0to 40 krad was attempted. Three types of changes were graded: impairment of capillary circulation, increase of permeability of trypan blue through the blood-brain barrier system, and necrosis. Comparison with the results of whole-head irradiation reported in the literature showed that radiation changes of surrounding structures may indirectly contribtite to the changes in the blood-brain barrier system in the region of study. The importance of performing experiments on the effects of local irradiation of the central nervous system under well defined conditions as regards localization and dosedistribution is therefore stressed. Circulatory- disturbances seem to precede the blue-staining of irradiated brain tissue. As a matter of further discussion a hypothetical mechanism in consistency with observation and modern concepts of the constitution of the blood-brain barrier system is out-lined. The mechanisms involved in the rapid development of lesions described here might be different from those involved in the production of late delayed radionecrosis. The results show that the detection of changes in the blood brain barrier system with suitable dyes or radioactive compounds may be applied as a means of early diagnosis of the radiolesion. (auth)
- Research Organization:
- Uppsala Univ. Gustaf Werner Inst. for Nuclear Chemistry
- NSA Number:
- NSA-14-011440
- OSTI ID:
- 4199278
- Report Number(s):
- AFOSR-TN-60-252
- Country of Publication:
- United States
- Language:
- English
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