RELATION OF HEPATIC KETOGENESIS TO RADIATION-INDUCED DECREASE IN FASTING KETONEMIA
Male, weanling rats were exposed to 500 r of wholebody x irradiation and then lasted. Control rats were concurrently fasted. Ketonemia, ketonuria, hypatic glycogen, ketogenesis by liver slices. and fatty acid oxidase activity of liver mitochondria were measured A radiationinduced decrease in tasting ketonemia was observed This decrease was mainly in the beta -hydroxybutyric acid friction Ketonuria was similar in both control and irradiated lots the lst postirradiation day and lower in the irradiated lot during the 2nd day. Decreased ketonemia in the irradiated rats, which exhibited diuresis, was thus apparently not due to increased urinary excretion of ketone bodies. Ketogene sis by liver slices from irradiated rats was depressed. This indicated than an antiketogenic process contributed to the radiation-induced decrease in lasting ketonemia. Fatty- acid oxidase activity of liver mitochondria isolated from control and irradiated rats was similar. Thus. ratelimiting fatty acid oxidizing enzymes were not altered by radiation under these conditions. This illustrates an apparent modifying effect of other cellular fractions on fatty acid oxidation in mitochondria. (auth)
- Research Organization:
- School of Aviation Medicine, Randolph AFB, Tex.
- NSA Number:
- NSA-14-007225
- OSTI ID:
- 4198304
- Journal Information:
- American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 198; ISSN AJPHA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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