Graft-versus-host reactions in mice. III. Epithelioid and multinucleated giant cells of thymic origin

Journal Article · Sun Apr 01 04:00:00 EST 1973 · Am. J. Pathol., v. 71, no. 1, pp. 119-134

OSTI ID:4182311

Bennett, M; Montes, M

Thymus cells from C3H donor mice were infused into lethally irradiated (C3H x C57BL/10)F$sub 1$ hybrid mice. Light and electron microscopic examination of the lymphoid tissues of recipients revealed the presence of epithelioid and multinucleated giant cells in addition to lymphocytes and histiocytes. Serial transplantation of thymus-derived cells into irradiated F$sub 1$ hybrid mice resulted in a preponderance of epithelioid cells over lymphocytes. Epithelioid cells, as well as lymphocytes and histiocytes, incorporated $sup 3$H-thymidine, indicating that they were actively proliferating. Following transplantation of CBA-T6T6 thymocytes into irradiated (C3H x C57BL/10)F$sub 1$ mice, karyotypic analysis of host lymphoid tissues indicated that all dividing cells were of donor origin. Whereas bone marrow is known to give rise to epithelioid cells in the absence of thymic influences, the thymus must also contain precursors of epithelioid cells. (auth)

• Research Organization: Roswell Park Memorial Inst., Buffalo
• NSA Number: NSA-33-005790
• OSTI ID: 4182311
• Journal Information: Am. J. Pathol., v. 71, no. 1, pp. 119-134, Journal Name: Am. J. Pathol., v. 71, no. 1, pp. 119-134; ISSN AJPAA
• Country of Publication: United States
• Language: English

Related Subjects

*GRAFT-HOST REACTION
*IMMUNITY-- BIOLOGICAL RADIATION EFFECTS
*IMMUNOSUPPRESSION-- RADIOINDUCTION
*THYMOCYTES-- CELL PROLIFERATION
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
LETHAL IRRADIATION
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
TRANSPLANTS
X RADIATION