Radioimmune assay of heterologous serum $gamma$-globulin in patients receiving rabbit antihuman thymocyte globulin
A radioimmune assay (RIA) method for detecting heterologous serum rabbit $gamma$-globulin (RG) and antibody to this protein is described. The methodology is used for monitoring serum levels of rabbit globulin in patients receiving rabbit ATG (RATG). In 7 cardiac recipients receiving RATG, maximum serum levels of RG were achieved 1 to 3 days after administration of final dose. RG half-life subsequent to peak serum levels was rapid (X = 36 hr) in 4 patients and prolonged (X = 18 days) in 3 patients. Patient antibody to rabbit $gamma$-globulin was detectable only in those patients with short RG half-life. Antirabbit antibody titers in these patients were extremely low and barely detectable by RIA. (auth)
- Research Organization:
- Stanford Univ., CA
- NSA Number:
- NSA-33-005889
- OSTI ID:
- 4175389
- Journal Information:
- Transplantation, v. 20, no. 5, pp. 393-398, Journal Name: Transplantation, v. 20, no. 5, pp. 393-398; ISSN TRPLA
- Country of Publication:
- United States
- Language:
- English
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