ACTION OF X-RAYS ON THE PLACENTAL BARRIER AT DIFFERENT STAGES OF PREGNANCY. MECHANISMS OF ACTION OF X-RADIATION ON THE TRANSFER OF P$sup 32$ THROUGH THE PLACENTAL BARRIER FROM MOTHER FOETUS
A single whole-body irradiation of pregnat animals with a lethal dose of x rays (rabbits with 850 to 1000 r and guinea pigs 600 r) depressed the uptake of P/sup 32/ by both placental tissues and fetus. X irradiation sharply de- . pressed incorporation of P/sup 32/ into the high molecular phosphorus compounds of the placental and fetal tissues. and increased the permeability of the placental barrier. The fall in the total radioactivity of the placental and fetal tissues after irradiation together with increased permeability of the placenta to P/sup 32/ was seen within 2 hr of the action of penetrating radiations and is to be explained by the sharp decline in the synthesis of high molecular phosphorus compounds. The modified permeability of the placental barrier due to irradiation was apparertly unrelated to changes in the activity of the enzyme hyaluronidase in the placenta. The most profound disturbances in the exchange of P/sup 32/ between mother and fetus following irradiation were manifest in the first half of pregnancy. (auth)
- Research Organization:
- Inst. of Biological Physics, Academy of Sciences, Moscow
- NSA Number:
- NSA-14-016548
- OSTI ID:
- 4163998
- Journal Information:
- Biophysics (U.S.S.R.) (English Translation), Vol. Vol: 4, No. 5; Other Information: Orig. Receipt Date: 31-DEC-60
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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