ROLE OF DISTURBANCES IN PYRIMIDINE METABOLISM IN RADIATION INJURY
The rate of incorporation of carbon from C/sup 14/O/sub 2/ into the purine and pyrimidine bases of DNA and RNA after gamma irradiation of plants was investigated. It was shown that on irradiation of plants with a dose of 10,000 r a sharp decline occurred in the first 24 hr in the specific activity of DNA thymine and RNA uracil. The specific activity of cytosine was insignificantly reduced and that of the purine bases showed almost no departure from the controls. An hypothesis is advanced on the basis of the results that in the first hours after irradiation synthesis of DNA and RNA takes place, producing compounds with abnormal nucleotide ratios. The possible significance in the subsequent development of radiation injury of the appearance of these modified compounds of DNA and RNA is discussed. (auth)
- Research Organization:
- (Tokarskaia)-Merenova (Inst. of Biological Physics, Academy of Sciences, Moscow
- NSA Number:
- NSA-14-013651
- OSTI ID:
- 4162259
- Journal Information:
- Biophysics (U.S.S.R.) (English Translation), Vol. Vol: 4, No. 4; Other Information: Orig. Receipt Date: 31-DEC-60
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
Infrared Spectroscopy of Charge Transfer Complexes of Purines and Pyrimidines
INTERRELATIONS OF NUCLEIC ACID AND PROTEIN SYNTHESES IN RADIATION INDUCED MUTATION INDUCTION IN BACTERIA