Medical Research and Evaluation Facility (MREF) and studies supporting the Medical Chemical Defense Program. Final report
Technical Report
·
OSTI ID:415910
Strong and well-defined agent dose 1O-hr lethality relations were observed in untreated animals for each agent. The 10-hr agent MLDs for untreated monkeys were estimated to be 80, 43, 8.0, 22, and 7.4 ug/kg for GA, GB, GD, GF, and VX, respectively. The 10-hr GD MLDs estimated for ATRI2-PAM and ATR/HI-6 treated monkeys were 10 and 13 ug/kg, respectively. Neither oxime provided protection against 2 x GD 10hr MLD. No lethality was observed in oxime-treated animals injected with either GF or VX, even though animals were given doses greater than 15 x agent MLD. Because of this, only four or five monkeys per oxime treatment were used in GF and VX experiments. Treatment with ATR/2-PAM or ATR/Hl-6 substantially affected the slope of the agent dose-lethality response curves for GA and GB. Larger sample sizes are required to estimate the shallow GA and GB dose lethality curves observed for oxime treated animals. For GA, 79 percent (11/14) of oxime treated animals injected with doses greater than 2 x 10-Hr MLD survived at least 10 hr. These data indicate that both oximes provide some protection against a 2 x GA lO-hr MLD. For GB, ATR/2-PAM treated animals were given doses ranging from approximately one to 13 x GB lO-hr MLD, and ATR/Hl-6 treated animals were administered GB doses ranging from approximately 0.73 to 2 x 1%hr MLD. In spite of the higher GB doses administered to ATRI2-PAM treated animals, survival was greater (718) than for ATR Hl% treated animals (518). All three of the ATR/-PAM treated animals injected with GB doses greater than 2 x 10hr MLD survived. The collected data indicate that ATR/2-PAM provides protection against a 2 x GB.
- Research Organization:
- Battelle Memorial Inst., Columbus, OH (United States)
- OSTI ID:
- 415910
- Report Number(s):
- AD-A--313953/2/XAB; CNN: Contract DAMD17-89-C-9050
- Country of Publication:
- United States
- Language:
- English
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