RADIATION LEUKEMOGENESIS. AN ANALYSIS OF THE PROBLEM

Journal Article · Sun May 01 04:00:00 EDT 1960 · American Journal of Medicine (U.S.)

DOI:https://doi.org/10.1016/0002-9343(60)90126-1· OSTI ID:4154261

Cronkite, E P; Moloney, W; Bond, V P

Data are now adequate to indicate that, for high level, single dose exposure of man, the incidence of leukemia is approximately linear with dose. At dose levels of perhaps 100 r equivalent or greater, the incidence is approximately 1 to 2/10/sup 6/ persons at risk/year/rad, at least from approximately the second to the fifteenth year following exposure. below dose levels of approximately 100 r equivalent, the available data are inadequate for prediction. Data are inadequate for prediction for other than the single acute dose, i.e., it is not known if a dose-rate dependency exists. It is not known if the risk continues beyond approximately the first fifteen years from exposure. Although there is evidence that large dose radiation of sizeable portions of the marrow may be leukemogenic, there are no adequate grounds for assuming that the highly localized radiation from internal emitters such as Sr/sup 90/ and radium are or are not leukemogenic. It is not pcssible to determine whether or not a threshold dose for the induction of leukemia does or does not exist. (auth)

• Research Organization: Brookhaven National Lab., Upton, N.Y.
• NSA Number: NSA-14-022761
• OSTI ID: 4154261
• Journal Information: American Journal of Medicine (U.S.), Journal Name: American Journal of Medicine (U.S.) Vol. Vol: 28; ISSN AJMEA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
BONE MARROW
CARCINOGENESIS
IRRADIATION
LEUKEMIA
NUMERICALS
RADIATION DOSES
RADIATION EFFECTS
RADIATION SICKNESS
RADIOACTIVITY
RADIOSENSITIVITY
RADIUM
STATISTICS
STRONTIUM 90