Some experience with $sup 57$Co-labeled bleomycin as a tumor-seeking agent
Bleomycin labeled with $sup 57$Co was used as a tumor-localizing agent in 132 patients. In patients with pulmonary tumors the primary localization concentrated radioactivity in 52 of the 54 appropriate cases; out of the 22 clinically known metastases, 19 were visible on the scan; 40 unknown metastases especially in hilus and mediastinum were found by this method and subsequently confirmed. In 22 patients with malignant lymphomas, 18 out of 22 known pathologic lymph glands above the diaphragm were visible on the scan; below the diaphragm the results of scanning in lymph glands and spleen were disappointing, probably because of the disturbing concentration of radioactivity in the kidneys, the bladder, the liver, and sometimes the gut. In 25 patients with various other tumors, 16 out of 22 known localizations above the diaphragm were visible; 2 were uncertain and 4 negative. Below the diaphragm the results were usually negative. In 24 patients with benign lesions, uptake of $sup 57$Co-bleomycin was visible on the scintigram in 4 patients with cavitating pulmonary tuberculosis, in 2 with pulmonary infections, in 1 with Caplan lesions of rheumatoid arthritis in the lung, and in 1 with sinusitis ethmoidalis. The significance of these results is discussed. (auth)
- Research Organization:
- University Hospital, Groningen, Netherlands
- NSA Number:
- NSA-33-007706
- OSTI ID:
- 4153773
- Journal Information:
- J. Nucl. Med., v. 16, no. 11, pp. 1058-1069, Journal Name: J. Nucl. Med., v. 16, no. 11, pp. 1058-1069; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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