THE SUPPRESSION BY CORTISONE OF THE ACUTE LOCAL RADIATION REACTION IN THE RABBIT EAR
The action of cortisone on the response of the skin of the rabbit ear to a single x-ray exposure was investigated. Gross and microscopic studies were done after tissue doses of 1000 to 30,000 r. Doses of 1 to 20 Mg of cortisone per day parenterally (and 2.5% looal cortisone) were starte and then discontinued over a period of 2 days prior to irradiation to 90 days postirradiation. These studies confirm the finding that cortisone will suppress ulceration over a range of radiation dosage and demonstrate a remarkable suppression of inflammation after the initial degenerative changes, as long as the cortisone is continued. The results indicate that inflammation is secondary to degeneration of cells and is suppressed locally. (auth)
- Research Organization:
- Univ. of Chicago
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-14-017762
- OSTI ID:
- 4150246
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Vol. Vol: 13
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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