THE EFFECT OF DOSE FRACTIONATION ON MUTATION INDUCTION
Somatic mutation rates at the leaf marking locus in Trifolium repens were determined following exposure to acute and fractionated doses of gamma radiation. Certain dose fractionation treatments led to a reduction in the number of mutations recovered, to a value below the base line of additive effects of the two fractions. Doses as low as 12.5 rads induced protection, and a somewhat similar degree of protection was produced by a range of initial doses. The phenomenon developed within a short period of time after irradiation, and its development was related to temperature. Mutations took longer to develop and persisted for a greater length of time at lower temperatures. The protective effect was observed only if the initial fraction was given in the presence of air or oxygen. Attempts were made to interpret the radiation induced protection in terms of induced metabolic changes within the tissues. (auth)
- Research Organization:
- Atomic Energy Research Establishment, Harwell, Berks, Eng.
- NSA Number:
- NSA-18-001441
- OSTI ID:
- 4148657
- Journal Information:
- Strahlentherapie, Sonderbaende, Vol. Vol: 51; Other Information: Orig. Receipt Date: 31-DEC-64
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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