ATTEMPT TO ACCELERATE THE EXCRETION OF RADIOIODINE FROM BODY OF EXPERIMENTAL ANIMALS

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Naturwissenschaften (West Germany)

DOI:https://doi.org/10.1007/BF00632095· OSTI ID:4146296

Setaelae, K; Kuikka, A O

The withdrawal of radioiodine from mice, utilizing the extrarenal mineral/fluid-balance regulatory system as a motor for excretion, is reported. A calibrated quantity of 0.5 mu c of I/sup 131/ was instilled intragastrically in a single dose in female mice. The extrarenal system was activated by the injection of 3 mg of pilocarpine. The saliva, stool, and cutaneous gland excretion were collected and examined for radioiodine concentration. The I/sup 131/ was rapidly picked up by the thyroid, and the maximum was reached 15 to 45 min after instillation. The radioactivity was excreted both in the urine and the stool. After injection of pilocarpine nitrate, large quantities of I/sup 131/ were excreted through the salivary glands and the excretory glands of the large intestine. Instillation of stable iodine together with specific activation increases the excretion of radioiodine through the extrarenal system. (J.S.R.)

• Research Organization: Univ. of Helsinki
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-004988
• OSTI ID: 4146296
• Journal Information: Naturwissenschaften (West Germany), Journal Name: Naturwissenschaften (West Germany) Vol. Vol: 50; ISSN NATWA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BODY
DRUGS
FECES
FLUIDS
GLANDS
INTESTINE
IODINE
IODINE 131
METABOLISM
MICE
PILOCARPINE
QUANTITY RATIO
RADIATION DOSES
SALIVA
SEX
SKIN
STOMACH
THYROID
URINE
VARIATIONS