Role of Oxygen in the Cross-linking and Degradation of Deoxyribonucleic Acid by Ionizing Radiations
When deoxyribonucleic acid in dilute aqueous solutions or in the solid state was irradiated, the presence of oxygen did not affect the reaction. With nucleic acid gels having a water content between these two extremes, oxygen was found to exert a pronounced influence on the change produced by irradiation with electrons at 1 Mev. As the water content was increased above 25%, main-chain scission with reduction in molecular weight became the predominant reaction of irradiation in air. When the gels were irradiated in the absence of oxygen, the molecular weight increased until some of the nucleic acid became so highly crosslinked that it no longer dissolved in dilute salt solutions but only swelled.
- Research Organization:
- Inst. of Cancer Research, London
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-14-025524
- OSTI ID:
- 4141333
- Journal Information:
- Nature (London), Journal Name: Nature (London) Journal Issue: 4741 Vol. 187; ISSN 0028-0836
- Publisher:
- Nature Publishing Group
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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