MUTATION INDUCED IN GERM CELLS OF THE FOETAL FEMALE MOUSE
In the absence of data concerning the genetically effective radiation dose to human germ cells, studies were made of induced mutations in the mouse, using the specific-locus method. Earlier studies of mutations induced in spermatogoria of the adult male were extended to include those induced in spermatogonia of fetal rules, in postspermatogonial cells of adult males, and in oocytes of adult females. The main conclusions reached are discussed in connection with radiation intensity and germ-cell stage. Data are tabulated for mutation at seven specific loci in germ cells of the female mouse and for comparison of induced mutation rate in the fetal female with those in the adult. It is clear that the germ cells of the fetal female mouse, irradiated under the conditions of the experiment, are not grossly more sensitive than those of the adult. (B.O.G.)
- Research Organization:
- Medical Research Council's Radiobiological Research Unit, HArwell, Berks, eng.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-001264
- OSTI ID:
- 4135929
- Journal Information:
- Genet. Research, Journal Name: Genet. Research Vol. Vol: 1
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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