Methylvinylsulphone derivatives. Synthesis of [$sup 14$C]-labelled methyl 2,2-diphenylvinylsulphone

Journal Article · Sun Dec 01 04:00:00 EST 1974 · Bull. Soc. Chim. Fr., no. 12, pp. 2923-2924

OSTI ID:4133688

Fillion, H; Luu Duc, C; Agnius-Delord, C

[$sup 14$C]-labelled methyl 2,2-diphenylvinylsulfone has been synthesised in order to study its metabolism. The various methods for its preparation are discussed. The action of the methyl-sulphinyl carbanion on [$sup 14$C]-benzophenone, prepared by Grignard synthesis, affords methyl-2-hydroxy-2,2- diphenylethyl sulphoxide, which is oxidised to sulfone by hydrogen peroxide. Dehydration of the sulfone, using phosphoric acid, leads to the required [$sup 14$C]-labelled vinylsulphone. (FR)

• Research Organization: Grenoble-1 Univ., 38 - La Tronche (France)); (Grenoble-1 Univ., 38 (France). Inst. des Isotopes Radioactifs
• NSA Number: NSA-33-011575
• OSTI ID: 4133688
• Journal Information: Bull. Soc. Chim. Fr., no. 12, pp. 2923-2924, Journal Name: Bull. Soc. Chim. Fr., no. 12, pp. 2923-2924; ISSN BSCFA
• Country of Publication: France
• Language: French

Related Subjects

*CARBON 14-- RADIOCHEMISTRY
*SULFONES-- LABELLING
400702* --Chemistry--Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
AROMATICS
CARBON 14 COMPOUNDS
CHEMICAL REACTION YIELD
METABOLISM
N40420* --Chemistry--Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
SYNTHESIS