RELATIVE BIOLOGICAL EFFECTIVENESS ON COMPACT EHRLICH-ASCITES TUMORS OF 250- kv AND 31-Mev X RAYS AND ELECTRONS (in German)
The influence of differert radiation qualities (250-kv x rays, 31-Mev x rays and 30-Mev electron radation) on the mitosis of compact Ehrlich-carcinoma of the mouse was exarmined. The doses were 200 r and 300 r. The observation time was extended to 48 hr radiation termination. The mnitosis values of the conventionally and 31-Mev x ray irradiated tumors show no statistically proved differences, even when the curve of the convertionally irradiated runs throughout somewhat deeper. Those irraiated with fast electrons, as opposed to the conventionally and 31-Mev x-ray irradiated, appear to exhibit a somewhat quicker recovery out of the mitosis depression. At the moment finding this is only for one curve-point of the doses of 200 r and 300 r statisticaily ascertianed The displacements of the mnitosis phases elapse in an equal sense by the different types of radiation. The controllable depression of the ana- and telo-phases up to 45 hours after radiation makes it probable that the further rise of the mitosis, which in our material is conditioned mainly through an increase of metaphass, is due rather to a temporal disturbance and eventual partial blocking in the celldivision course than to a further revivinig cell-division activity. The RBE of the different radiation qualities on the mitosis remains the same if the carcinoma is radiated solely as a compact tumor as if it is influenced as ascites tumor by a total.radiation. The effset is realized therefore directly upon the tumor and not through the general action by total radiation. On the grounds of the observation that the conventional and ultrahand x rays in the mitosis effect of the compact Ehrlich-carcinoma scarcely differertiate themselves, while on the other hand the effect of the conventional x rays on the growth-inhibition of the same tumor is significantly stronger, the conclusion is that the radia tion action on the tumor remission is not evaluated in the first place as a mitosis effect but is to be considered essentially as an effect on the cell-nuclei in inactivity. (auth)
- Research Organization:
- Universitat, Bern
- NSA Number:
- NSA-15-002500
- OSTI ID:
- 4132422
- Journal Information:
- Strahlentherapie (West Germany), Journal Name: Strahlentherapie (West Germany) Vol. Vol: 113; ISSN STRAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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