Investigations on the influence of aminopropyl-aminoethyl-phosphorothioic acid on the radio-iron utilization after a whole-body irradiation of mice in the sublethal dose range (in German)
The effectiveness of the thiophosphate compound WR 2721 was investigated with regard to the radiosensitivity of X-irradiated female mice in the sublethal dose range of 50 to 150 R using the radioiron test ($sup 59$Fe). An increase of the radioresistance with regard to the radioiron uptake in young erythrocyte populations was obtained only beyond radiation doses of 75 R. In lower dose ranges the animals treated with thiophoshate became even more radiosensitive. At dose values of 100 R and 150 R dose reduction factors (DRF) of 1.3 and 1.5 respectively were obtained. These factors are considerably smaller than the DRF- values found for the survival rate at LDsub(50/30). A possible mechanism for this result may be due to the different dephosphorylation rate of the thiophosphate in various tissues, as described in literature. (orig.)
- Research Organization:
- Freiburg Univ. (F.R. Germany). Inst. fuer Biophysik und Strahlenbiologie
- NSA Number:
- NSA-33-009549
- OSTI ID:
- 4130703
- Journal Information:
- Strahlentherapie, v. 150, no. 1, pp. 44-50, Other Information: 1 fig.; 3 tabs.; 21 refs. Orig. Receipt Date: 30-JUN-76
- Country of Publication:
- Germany
- Language:
- German
Similar Records
The distribution and metabolism of the radiation protective agent aminopropylaminoethyl-phosphorothioate (WR-2721) in mice. Final report, July 1967-June 1972
Sodium hydrogen-S-(3-amino-3-hydroxypropyl) phosphorothioate (WR-77913): toxicity and bone marrow radioprotection. [/sup 60/Co]
Related Subjects
560152* -Biomedical Sciences
Applied Studies-Radiation Effects-Radiation Effects on Animals-Vertebrates
*ERYTHROCYTES- SUBLETHAL IRRADIATION
*MICE- RADIOSENSITIVITY
*THIOPHOSPHORIC ACID ESTERS- RADIOSENSITIVITY EFFECTS
DOSE-RESPONSE RELATIONSHIPS
FEMALES
IRON 59
RADIONUCLIDE KINETICS
UPTAKE
WHOLE-BODY IRRADIATION
X RADIATION