Anorexia in rats after protracted whole-body irradiation with low doses

Journal Article · Tue Jul 01 04:00:00 EDT 1975 · Strahlentherapie, v. 150, no. 1, pp. 87-90

OSTI ID:4126128

Schraub, A; Sattler, E L; Doell, G; Kindt, A; Giessen, U

In our experiments, carried out hitherto, concerning the effect of incorporated and radioactive substances, weight behaviour and food uptake have proved to be a sensitive test. With regard to these experiments and the half- life of the radionuclides used, it is reported about trial series in Wistar rats. These rats were applied, with Co-60 gamma irradiation, different whole-body doses protracted over 48 hours. A total of 32 groups of experimental animals (20 animals each) was exposed to irradiation doses of lethal, medium lethal, and sublethal ranges, control and pseudo-irradiation series included. The experiments were carried out under observance of constant irradiation and attitude conditions, night and day changes, as conditioned by the season, included. Even in the inferior sublethal range (12 to 24 R), a significant trend of decreased food uptake is registered. This trend remains for a short period after the end of irradiation, but then it returns to normal conditions. Furthermore, a new decrease with subsequent increase seems to become evident - about ten days after termination of the radiotherapy (especially after several hundred R); report about these items will be made later on. (orig.)

• Research Organization: Giessen Univ. (F.R. Germany). Strahlenzentrum; (F.R. Germany). Inst. fuer Biophysik
• NSA Number: NSA-33-009553
• OSTI ID: 4126128
• Journal Information: Strahlentherapie, v. 150, no. 1, pp. 87-90, Journal Name: Strahlentherapie, v. 150, no. 1, pp. 87-90; ISSN STRAA
• Country of Publication: Germany
• Language: German

Related Subjects

*ANOREXIA-- RADIOINDUCTION
*RADIOTHERAPY-- SIDE EFFECTS
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
BIOLOGICAL RADIATION EFFECTS
GAMMA RADIATION
LOW DOSE IRRADIATION
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
RADIATION DOSE UNITS
RATS
TIME DEPENDENCE
WHOLE-BODY IRRADIATION