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Spermatogonial stem cell renewal in the mouse as revealed by $sup 3$H- thymidine labeling and irradiation

Conference ·
OSTI ID:4125143
;
Procedures are described for sectioning and staining mouse testes, x- irradiation of mice, and classification of developing sperm cells. Tables are presented to show frequency of labeled cells following exposure to various doses of x radiation. A discussion is presented of types of spermatogonia surviving various radiation doses and times of incorporation of $sup 3$H-TdR in the cycle of the seminiferous epithelium. Models of stem cell renewal systems are described. (HLW)
Research Organization:
Oak Ridge National Lab., Tenn. (USA); Baylor Univ., Houston, Tex. (USA). Coll. of Medicine
NSA Number:
NSA-33-012385
OSTI ID:
4125143
Report Number(s):
CONF-751037--1
Country of Publication:
United States
Language:
English

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Related Subjects

*SPERMATOGENESIS-- BIOLOGICAL RADIATION EFFECTS
*SPERMATOGONIA-- CELL PROLIFERATION
*STEM CELLS-- CELL PROLIFERATION
*TESTES-- BIOLOGICAL RADIATION EFFECTS
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
DOSE-RESPONSE RELATIONSHIPS
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
SPERMATOZOA
SURVIVAL TIME
THYMIDINE
TRACER TECHNIQUES
TRITIUM
X RADIATION