MALFORMATION OF THE EXTREMITY IN THE MOUSE FETUS CAUSED BY X-RADIATION OF THE MOTHER DURING PREGNANCY

Journal Article · Sun Sep 01 04:00:00 EDT 1963 · J. Embryol. Exptl. Morphol.

OSTI ID:4121501

Murakami, U; Kameyama, Y; Nogami, H

Mice were exposed to x radiation of 300, 200, and 150 r from the 8th to 13th day of pregnancy. X rays were produced by a therapeutic x-ray machine of 170 kvp, 10 ma, at 16 r/min. In offspring from mothers treated on the 11th day, malformations of the extremities were observed in groups treated with over 200 r. In offspring from mothers treated on the 12th day, digital reductions, on account of ectrodactylias, were the typical malformation in the forelimb. In the hind- limbs, the incidence was a little lower and the predominant site of involvement was the third digit. Other digital malformations occurred more often in the hind- limb than in the fore-limbs, though not frequently. The formation of ectrodactylias after x irradiation was studied in a follow-up experiment. The process began with cellular necrosis in the hand and foot plate corresponding second digit of the fore-limb and in the third digit of the hind-limb. The process may damage the precursor of the precartilage. In contrast to the regenerative neural tissue, compensation does not take place in the mesenchymal tissue once the destruction is severe, and the reduction of digits will therefore persist. The effect of x radiation upon a developing digital primordium may be a directly destructive process. The critical stage for extremity malformations due to thalidomide in human beings corresponds with the critical stage for x-ray malformations of the extremities in mouse. The pattern of malformations caused by x radiation was also found to be similar to that produced by riboflavin deficiency, but with some additional skeletal changes such as humero-radial synostosis. (BBB)

• Research Organization: Nagoya Univ., Japan
• NSA Number: NSA-18-011739
• OSTI ID: 4121501
• Journal Information: J. Embryol. Exptl. Morphol., Journal Name: J. Embryol. Exptl. Morphol. Vol. Vol: 11
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BONES
DRUGS
FETUSES
MALFORMATIONS
MAN
MICE
NERVOUS SYSTEM
PREGNANCY
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
REGENERATION
SEX
TISSUES
VITAMIN B-2
VITAMINS
X RADIATION