Does x radiation of the preconceptional mammalian ovum lead to sterility and/or congenital anomalies

Journal Article · Sun Jun 01 04:00:00 EDT 1975 · Fert. Steril., v. 26, no. 6, pp. 560-572

OSTI ID:4117316

Rugh, R; Budd, R A

It is now well established that x radiation of the developing mammalian embryo or early fetus can lead to congenital anomalies. Incidental to x radiation of the pregnant animal, the gonads of the developing fetus and the adjacent mature gonads of the mother are also exposed. Reports of the effects of such x radiation on the prefertilized ovum and oocytes have appeared, but none has been aimed specifically at determining the degree and onset of sterility and the incidence of resorptions and congenital anomalies. It is the purpose of this study to answer these questions relating both to the immediate effects on the gonads and any persistent postradiation effects on the offspring of the parental stock, as well as sterility and anomalies that might occur among the F$sub 2$ generation as a result of brother and sister matings. The results of this study provide experimental insight into the possible consequences to fertilizability of exposure of the unfertilized ovum or earlier oocyte and the possibility that exposure causes the development of congenital anomalies. (auth)

• Research Organization: Bureau of Radiological Health, Rockville, MD
• NSA Number: NSA-33-017451
• OSTI ID: 4117316
• Journal Information: Fert. Steril., v. 26, no. 6, pp. 560-572, Journal Name: Fert. Steril., v. 26, no. 6, pp. 560-572; ISSN FESTA
• Country of Publication: United States
• Language: English

Related Subjects

*CONGENITAL MALFORMATIONS-- RADIOINDUCTION
*OVA-- BIOLOGICAL RADIATION EFFECTS
*REPRODUCTION-- BIOLOGICAL RADIATION EFFECTS
*STERILITY-- RADIOINDUCTION
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
WHOLE-BODY IRRADIATION
X RADIATION