THE EFFECT OF CYSTEINE ON THE RADIOINDUCED MUTATION RATE IN ESCHERICHIA COLI (in German)
Journal Article
·
· Strahlentherapie (West Germany)
OSTI ID:4109522
A leucin dependent shortage-mutant II-20 and a streptomycin dependent mutant X-41 were isolated from a relatively radiation resistant species E. coli B/ r. The protective action of cysteine (0.01-m) on the original species as well as on the leucin dependent mutants was examined at doses up to 80,000 r with reference to the inactivation of the bacteria. Cysteine caused in the whole dose range a significant decrease of the inactivation rate. Thereafter the reverse mutation rate to the wild type after radiation was examined with the same dose range on both mentioned biochemical mutants. Application of cysteine before radia tion reduced the number of the reverse mutations considerably. Application of cysteine without radiation brings about no change of the spontaneous mutation rate. (auth)
- Research Organization:
- Universitats-Frauenklinik, Hamburg-Eppendorf, Ger.
- NSA Number:
- NSA-15-008571
- OSTI ID:
- 4109522
- Journal Information:
- Strahlentherapie (West Germany), Journal Name: Strahlentherapie (West Germany) Vol. Vol: 114; ISSN STRAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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