Metabolism of Te132-I132 in lactating sheep
Lactating ewes were administered a single oral dose of Te132-I132 containing small amounts of Te131 and I131. C oncentrations in the milk were measured during the first 4 days post ingestion. Less than 0.2% of the administered Te132 was secreted in milk for any 24 hr period. Comparative values reported for dairy cattle are 0.5% of the administered dose secreted during the first 6 days. Peak milk concentrations occurred between 24 and 36 hr after administration after which Te132 concentrations declined with an apparent half life of about 1 day. Plasma concentrations were approximately equal to those of milk for each sampling period. Although high concentrations of I132 were found in the milk at collection, with its rapid decay rate (2.2 hr half life), the concentration present 24 hr was dependent on the content of Te132. The ratio of I131 to Te132 in the milk varied from 120 at 1 day after administration to p 132 concentration in major tissues were performed for ewes sacrificed at 48, 72, and 96 hr after the Te132 administration. The highest concentration at 48 hr was found in the thyroid, kidney, and liver, which contained 0.006, 0.0014, and 0.004% of the administered dose per g, respectively. From these results and work on dairy cattle, it appears that Te132-I132 would not represent a significant hazard to man following a contamination event involving pastures grazed by lactating animals.
- Research Organization:
- General Electric Co., Richland, Wash.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-008085
- OSTI ID:
- 4106319
- Report Number(s):
- HW-SA-3073; 0017-9078
- Journal Information:
- Health Physics (England), Journal Name: Health Physics (England) Vol. Vol: 9; ISSN HLTPA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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