EFFECT OF CHLORAMPHENICOL ON GROWTH AND NUCLEIC ACID SYNTHESIS IN NORMAL AND ULTRAVIOLET CELLS OF VIBRIO CHOLERAE
Journal Article
·
· Indian J. Exptl. Biol.
OSTI ID:4100589
Chloramphenicol was shown to significantly inhibit DNA synthesis and to some extent RNA synthesis in normal cells of Vibrio cholerae. In the case of ultraviolet-irradiated cells, chloramphenicol almost completely prevents the recovery of DNA synthesis from the effects of irradiation and inhibits RNA synthesis almost to the same extent as in the normal cells. The incorporation of C/sup 14/-adenine, specifically taken up by the nucleic acids, is also inhibited by chloramphenicol in both normal and irradiated cells. However, chloramphenicol prevents the abrupt decline of optical density in the case of irradiated cultures during the later stages of growth, presumably due to lysis. (auth)
- Research Organization:
- Central Drug Research Inst., Lucknow, India
- NSA Number:
- NSA-18-009862
- OSTI ID:
- 4100589
- Journal Information:
- Indian J. Exptl. Biol., Journal Name: Indian J. Exptl. Biol. Vol. Vol: 1
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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