HEPATIC LIPOGENESIS IN D$sub 2$O-FED MICE
Swiss mice were maintained on a regimen of 25% D/sub 2/O for three weeks. The mice were slightly smaller than H/sub 2/O-fed controls, but the liver weight to body weight ratio was greater. There were no significant differences in liver lipid or cholesterol. Histologic examination showed progressive vacuolization and loss of basophilia, with changes in the mitochondrial distribution in the cytoplasm. These alterations did not show any specific localization in the hepatic lobule. There was a progressive reduction in the ability of liver homogenates from D/sub 2/O-fed mice to convert acetate-2-C-14 to cholesterol and fatty acid. Incubation of normal mouse livers in media containing 75% D/sub 2/O resulted in significant enhancement of cholestero1 and fatty acid biosynthetic capacity. This reduced lipogenesis in D/sub 2/O-fed mice appears to be due to derangements in cell structure, rather than to inhibition of enzyme activity. (auth)
- Research Organization:
- Veterans Administration Hospital, Philadelphia; Wistar Inst. of Anatomy and Biology, Philadelphia
- NSA Number:
- NSA-15-010656
- OSTI ID:
- 4094126
- Journal Information:
- Annals of the New York Academy of Sciences (U.S.), Vol. Vol: 84; Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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