THE USE OF IODINE-125 AS A DIAGNOSTIC AGENT IN OPHTHALMOLOGY

Journal Article · Fri Mar 01 04:00:00 EST 1963 · Trans. Am. Acad. Ophthalmol. Otolaryngol.

OSTI ID:4093093

Newell, F W; Goren, S B; Brizel, H E; Harper, P V

The use of radioactive isotopes in ophthalmoiogy has been restricted by the physical properties of the radioactive compounds available. Beta-emitting compounds, such as radiophosphorus (P/sup 32/), are mainly useful in abnormalities of the anterior ocular segment. Gamma-emitting compounds are of value only if significant quantities are retained by ocular tissue, with the remainder being rapid excreted. Under these conditions, the radioactive target within the eye would not be obscured by surrounding radi tion, particularly that emanating from the intracranial circulation. Although P/sup 32/ has often been useful in the diagnosis of anterior segment neoplasms, its application to posterior segment and orbital tumors has been disappoint ing. Subconjunctival dissection, rotation of the globe, an curved probes sometimes allow counting over the lesion but often do not. The probe used to measure the radioactivity must be in close proximity to the neoplasm. The test has proved to be of no value in the differential diagnosis of retinoblastoma. Its accuracy is reduced in the presence of active ocular inflammatory disease, following ocular surgery, and in one-eyed patients. Characteristics favorable to clinical use of radioisotopes are listed. lodine-125 in most of these respects qualifies as an excellent isotope for ocular use. It may be substituted advantageously for P/sup 32/ or I/ sup 131/ in many clinical and experimental situations in ophthalmology. The use of diiodofluorescein labeled with I/sup 125/ for detection of intraocular tumors is described; the procedure for its use is given in detail; and results in 39 patients are revealed. In the 19 patients with histologic evidence of neoplasm the test was correctly positive in 15 and a false negative result occurred in 4, an overall accuracy of 79%. In 20 patients with a variety of non-neoplastic ocular diseases there were no positive tests. Successful results are also reported on the efficacy of I/sup 125/-labeled diiodofluorescein as a diagnostic agent in the laboratory, the V-2 rabbit carcinoma being used as an experimental model. Clinical results of tests using I/sup 125/labeled tetracycline are also described. (BBB)

• Research Organization: Argonne Cancer Research Hospital, Chicago
• NSA Number: NSA-18-013600
• OSTI ID: 4093093
• Journal Information: Trans. Am. Acad. Ophthalmol. Otolaryngol., Journal Name: Trans. Am. Acad. Ophthalmol. Otolaryngol. Vol. Vol: 67
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BETA DECAY
BIOLOGY AND MEDICINE
BLOOD CIRCULATION
BRAIN
CANCER
DIAGNOSIS
DISEASES
DYES
EYES
FLUORESCENCE
GAMMA RADIATION
IODINE 125
IODINE 131
MALFORMATIONS
MEASURED VALUES
ORBITS
ORGANIC IODINE COMPOUNDS
PHOSPHORUS 32
RADIOACTIVITY
RETINOBLASTOMAS
SURGERY
TETRACYCLINES