USE OF THE ERYTHROCYTE T3-$sup 131$I UPTAKE TEST FOR EVALUATING THYROID FUNCTION IN RATS. ITS APPLICATION TO A STUDY OF THE EXTRATHYROIDAL ACTION OF PROPYLTHIOURACIL

Journal Article · Sun Mar 01 04:00:00 EST 1964 · Endocrinology (U.S.)

DOI:https://doi.org/10.1210/endo-74-3-415· OSTI ID:4090520

Saxena, K M; Crawford, J D; MacGillivray, M H

The Hamolsky erythrocyte T3-I/sup 131/ uptake test was modified to permit use of reduced volumes of arterialized blood and was found to be a reliable index of metabolic status in rats suitable for performing serial evaluations of individual animals. Results of the erythrocyte T3-I/sup 131/ uptake test, together with observations of activity and growth and determination of gland weight, I/sup 131/ gland uptake and serum protein-bound iodine (PBI) in rats given T3, T4 and propylthiouracil (PTU) suggest that PTU almost fully inhibited the metabolic effects of daily doses of 10 mu g of T4 but had little effect on response to 5 mu g of T3. The erythrocyte T3-I/sup 131/ uptake in contrast to the PBI showed direct correlation with clinical evaluation of the animals' metabolic status. (auth)

• Research Organization: Massachusetts General Hospital, Boston
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-013425
• OSTI ID: 4090520
• Journal Information: Endocrinology (U.S.), Journal Name: Endocrinology (U.S.) Vol. Vol: 74; ISSN ENDOA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BINDING ENERGY
BIOLOGY AND MEDICINE
BLOOD
BLOOD SERUM
DRUGS
ERYTHROCYTES
IODINE
IODINE 131
LABELLED COMPOUNDS
MEASURED VALUES
METABOLISM
ORGANIC IODINE COMPOUNDS
PHYSIOLOGY
PROPYL RADICALS
PROTEINS
RATS
TESTING
THIOURACIL
THYROID
USES
VARIATIONS
VOLUME
WEIGHT