DELETERIOUS INFLUENCE OF ORALLY ADMINISTERED TRITIATED THYMIDINE ON REPORDUCTIVE CAPACITY OF MICE
Tritiated thymidine was administered chronically in drinking water at a concentration of 2 mu c/ml to normal adult mice before and during the course of gestation. Under the conditions of the experiment, the approximate oral doses of H/sup 3/ to females ranged from 245 to 300 mu c over periods of from 24 to 32 days. During their contact with the females, adult male breeders also consumed the labeled thymidine solution in quantities ranging from 8 to 167 mu c over periods of from 1 to 18 days. No information is available to indicate the absolute body burdens which these oral dose levels represent. Delivery of apparently normal litters of young followed the first mating experiment, during which both males and females had received tritiated thymidine. However, in subsequent breeding contacts between the treated males and females, as well as between treated males and normal stock females, there was a rapid decline in reproductive capacity, which was characterized by an increased incidence of stillbirth, fetal resorption, and male sterility. Preliminary histological investigation has confirmed the existence of testicular damage in the treated males at the highest dose levels. A radiation-induced alteration of uterine function is suggested as being responsible for the prolongation of parturition, which was observed in two of the thymidine treated females and which led to the delivery of stillborn litters. The offspring resulting from the initial successful breeding experiment were themselves interbred on attaining sexual maturity. Their reproductive capacity was also markedly reduced, as evidenced by an incidence of stillbirth and neonathl death approximating 70%. (auth)
- Research Organization:
- Univ. of California, Los Angeles
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-010664
- OSTI ID:
- 4090409
- Journal Information:
- Radiation Research, Vol. Vol: 14; Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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