Bone and marrow imaging in sickle cell disease: diagnosis of infarction

Journal Article · Thu Jan 01 04:00:00 EST 1976 · Semin. Nucl. Med., v. 6, no. 1, pp. 83-93

DOI:https://doi.org/10.1016/S0001-2998(76)80038-4· OSTI ID:4089324

Lutzker, L G; Alavi, A

Sickling of erythrocytes in patients with S-hemoglobin causes marrow and bone infarction. The former can be demonstrated as a lack of /sup 99m/Tc-sulfur colloid uptake on marrow imaging examination. These defects may resolve or persist long after the acute episode. If the bone is involved in the acute episode, imaging within the first few days of onset of symptoms can show lack of / sup 99m/Tc-labeled phosphate uptake, usually in a smaller area than that shown by marrow scanning. Follow-up bone imaging shows increased activity, particularly along the circumference of the bone where periosteal reaction can be demonstrated radiographically. Magnification by use of the pinhole collimator provides better definition of the uptake defect and the distribution of the increased reactive uptake. Timing of examination is important. If marrow imaging is performed in an asymptomatic period, the repeat examination during a painful crisis permits differentiation of old and acute marrow infarction. If /sup 99m/Tc-phosphate imaging is performed after about 2 days of symptoms, acute infarction can be differentiated from osteomyelitis, which it may mimic clinically. To assist in differentiating bone infection in a site of marrow infarction demonstrated by marrow imaging, serial bone imaging with magnification may be useful. The uptake defect, followed in several days to 2 weeks, by circumferential increased activity, is a different pattern than the homogeneously intense activity of osteomyelitis, but the peripheral distribution may not be apparent on routine imaging. It is hoped that the utilization of these techniques can decrease the emotional and economic costs of prolonged hospitalization for suspected infection and can also expand our knowledge of the complex pathophysiologic changes of sickle cell bone disease. (auth)

• Research Organization: Albert Einstein Coll., Bronx, NY
• Sponsoring Organization: USDOE
• NSA Number: NSA-33-020603
• OSTI ID: 4089324
• Journal Information: Semin. Nucl. Med., v. 6, no. 1, pp. 83-93, Journal Name: Semin. Nucl. Med., v. 6, no. 1, pp. 83-93; ISSN SMNMA
• Country of Publication: United States
• Language: English

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