ON THE CHANGE OF ADRENAL FUNCTION IN ACUTE RADIATION INJURY

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Radiobiol. Radiotherap.

OSTI ID:4088994

David, G; Faradi, L; Tanka, D

Corticosterone levels in effluent adrenal vein blood were followed in rats following LD/sub 50/30/ (800-r) whole-body x irradiation. Steroid synthesis was also measured in adrenal slices of these rats. Changes in the corticosterone content of the venous blood showed two phases during radiation sickness: an increase the fifth day and on the tenth day normalization of surviving rats. The changes of the hormone-synthesizing ability also showed two phases: increase increase in the first 24 hr postirradiation and a slight increase later. Histological and histochemical examinations showed necrobiotic and hyperplastic changes in the adrenal gland. The values for hormone production and the clinical course both affirmed that in the early phase the hormone-syrthesizing capacity of the adrenal glands is heightened; the glands, however, do not secrete the hormone into the circulation. At the beginning of radiation disease the hormone output is markedly increased; hormone synthesis, however, is normal. In the third phase with recovery from the disease, the hormone secretion and syrthesis are nearly normal. With cases later ending fatally the synthesizing capacity may remain unchanged, whereas the hormone output practically stops. Some discrepancies between the hormone production and the histological findings were noted. (BBB)

• Research Organization: Rheumatology and Balneology Inst., Budapest
• NSA Number: NSA-18-013540
• OSTI ID: 4088994
• Journal Information: Radiobiol. Radiotherap., Journal Name: Radiobiol. Radiotherap. Vol. Vol: 3
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

ADRENAL GLANDS
BIOLOGY AND MEDICINE
BODY
CORTICOSTEROIDS
CYTOLOGY
HORMONES
IRRADIATION
METABOLISM
RADIATION DOSES
RADIATION INJURIES
RADIATION SICKNESS
RATS
STEROIDS
WHOLE-BODY IRRADIATION
X RADIATION