BREEDING EXPERIMENTS ON MEDICINAL PLANTS. 27. ROENTGEN MUTATIONS AND ACTIVE SUBSTANCE CONTENT IN DATURA (in German)
The changes in alkaloid content of the Datura stramonium var. godronii are considered. About 1000 plants cultivated from irradiated and nonlrradiated seeds were examined for changes in total alkaloid content. In about 1.5% of the plants the alknloid content changed considerably, the decreases being more marked than the increases. Completely alkaloid-free plants, however, were not produced, in spite of the fact that occasionally the alkaloid content was so low that it could no longer be determined. There were two groups of mutants with increased alkaloid content. Some pharmaceutically important plants with higher total alkaloid production per plant and with lowered alkaloid drug yield had double chromosome numbers and proved to be autotetraploid. However, the alkaloid contents of these plants were not higher than those of the artificially cultivated polyploids. The alkaloid content was evaluated by paper chromatography, which made possible the extraction of minute amounts of water- soluble basic amines as well as preventing the secondary changes of alkaloids. New alkaloids were not detected. Scopolamine content was found to decrease with age of the plant. In some mutants a reciprocal change in the amounts of some alkaloids could be demonstrated. A mutant containing a large amount of cuskohygrine was detected. (BBB)
- Research Organization:
- Universitat, Bern
- NSA Number:
- NSA-18-013523
- OSTI ID:
- 4083186
- Journal Information:
- Pharmaceutica Acta Helvetiae (Switzerland), Journal Name: Pharmaceutica Acta Helvetiae (Switzerland) Vol. Vol: 36; ISSN PAHEA
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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