EFFECTS OF ANTI-OXIDANTS ON RESISTANCE TO RADIATION INJURY

Technical Report · Fri Mar 01 04:00:00 EST 1963

OSTI ID:4082999

Ershoff, B H; Bajwa, G S

Since BHT (butylated hydroxytoluene) and certain other antioxidants significantly prolonged the average survival time of mice exposed to multiple sublethal doses of total body x irradiation, experiments were undertaken to determine the effects of antioxidants of diverse structure and activity and antioxidant synergists on length of survival following continuous exposure to a lethal dose of totalbody gamma radiation in the rat. BHT when fed at a 0.5% level in a purified diet and ascorbic acid at a 0.1% level significantly increased the average survival time of irradiated rats over that of rats fed the unsupplemented purified diet. Polygard (tri(nonylated phenyl)phosphites) when fed at levels of 0.25% and 0.5% and citric acid and phosphoric acid at levels of 0.1% in the purified diet also appeared to have some activity in this regard. Other antioxidants tested had little if any protective effect. The average survival time of irradiated rats was significantly longer for rats fed a natural food stock ration than for those fed the basal purified diet. No correlation was observed between the weight increment, organ weights, or microscopic appearance of the tissues of irradiated rats with length of survival on any of the diets employed. (auth)

• Research Organization: Western Biological Labs., Culver City, Calif.
• NSA Number: NSA-18-013562
• OSTI ID: 4082999
• Report Number(s): AMRL-TDR-63-28; AD-410008
• Country of Publication: United States
• Language: English

Related Subjects

ANTIOXIDANTS
BIOLOGY AND MEDICINE
BODY
BUTYL RADICALS
CHEMICALS
GAMMA RADIATION
HYDROXIDES
IRRADIATION
MICE
OXIDATION
RADIATION DOSES
RADIATION INJURIES
RADIATION PROTECTION
RADIOPROTECTIVE SUBSTANCES
RATS
SURVIVAL TIME
TOLUENE
VITAMIN C
VITAMINS
X RADIATION