THE RADIOSENSITIZING EFFECT OF THIOGLYCOLIC ACID, DITHIODIGLYCOLIC ACID, AND HOMOCYSTINE ON MUSCLE GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE

Journal Article · Mon May 01 04:00:00 EDT 1961 · Intern. J. Radiation Biol.

DOI:https://doi.org/10.1080/09553006114551171· OSTI ID:4071588

Lange, R; Pihl, A

BS>It is demonstrated that thioglycolic acid and its disulphide, dithiodiglycolic acid, and homocystine, have a pronounced radiosensitizing effect on the x-ray inactivation of crystalline rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase in solution. A number of other thiols and disulphides tested exert a protective effect. The radiosensitization observed is associated with a disappearance of free enzyme SH-groups, which can be reversed by addition of excess thiols after the radiation exposure. The data indicate that the sensitizing mechanism involves a blocking of essential enzyme SH-groups through a radiochemical formation of mixed disulphides between the enzyme SH-groups and the radiosensitizing substances. (auth)

• Research Organization: Norwegian Radium Hospital, Radiumhospitalet, Norway
• Sponsoring Organization: USDOE
• NSA Number: NSA-15-022038
• OSTI ID: 4071588
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 3
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMINO ACIDS
BIOLOGY AND MEDICINE
ENZYMES
MUSCLES
ORGANIC ACIDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATION PROTECTION
RADIOCHEMISTRY
RADIOSENSITIVITY
SULFIDES
THIOLS