RADIOSENSITIVITY AND METABOLIC PROPERTIES OF TWO TUMOUR-TYPES INDIGENOUS TO THE SAME HOST. I. A CORRELATION OF CELLULAR STRUCTURE AND RADIOSENSITIVITY
The radiosensitivity and metabolic properties of two types of mouse mammary tumors, epithelial (DBAH) and spindle (DBAG), both indigenous to the same host, are under extensive study. The cytological response of these tumors to 500, 1000, and 3000 r is described. The spindle-tumor cells (DBAG) proved to be more radiosensitive and produced unusually abnormal mitotic figures, unipolar and multipolar. Electromicrographs of this tumor revealed a paucity of mitochondria and their inferior quality, thereby explaining their extremely low capacity to phosphorylate in comparison with the epithelial tumor (DBAH). It is postulated that the quantity and quality of mitochondria play a significant roll in cellular radiosensitivity. Thus the chromosomal imbalance may not be the only factor in cell-death induced by irradiation. This posthlate is supported by observations on the tumors. (auth)
- Research Organization:
- Cancer Research Lab., New York; and New York Univ., New York
- NSA Number:
- NSA-15-014135
- OSTI ID:
- 4067604
- Journal Information:
- Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 3
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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