EXPERIMENTAL STUDY OF PROTECTIVE EFFECT OF 1-METHYL-2-MERCAPTOIMIDAZOLE ON RADIATION SICKNESS. I. A STUDY OF CHEMICAL PROTECTION AND RESTORATION AGAINST RADIATION INJURIES
The protective effect of 1-methyl-2-mercaptoimidazole (MI) on radiation sickness was investigated, using mice and rats. The effect of MI was compared with that of methyl-thiouracil (MT) under the same experimental con ditions. The administration of MI before irradiation caused marked prolongation of life span. Some favorable influence upon maintenance of the body weight also resulted. The administration of MI caused reduction and early recovery of leukopenia, particularly lymphopenia, following irradiation. In the pathological findings MI showed a marked protective effect against a loss of weight and the histological picture of the spleen. However, no definite effect was found on the changes of the liver and thyroid gland after irradiation. On the other hand the administration of MT caused no protective effect on radiation injuries. Both agents inhibited the thyroid function, with MT being more effective. (Absts. Japan. Med., 1: No. 7, 1960.)
- Research Organization:
- Kurume Univ., Japan
- NSA Number:
- NSA-15-022172
- OSTI ID:
- 4067463
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Vol. Vol: 19; Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
Study on the induction of thyroid tumors in rats using x irradiation in conjunction with a goitrogen. [1 methyl--2 mercaptoimidazole (methimazole)]
THE EFFECT OF INTRAVENOUS INTRODUCTION OF NOVOCAIN ON THE COURSE OF RADIATION SICKNESS