Uteroplacental blood flow during alkalosis in the sheep

Journal Article · Thu May 01 04:00:00 EDT 1975 · Am. J. Physiol., v. 228, no. 5, pp. 1497-1500

OSTI ID:4060956

Buss, D D; Bisgard, G E; Rawlings, C A; Rankin, J H.G.

Uteroplacental blood flow was measured by the radioactive-microsphere technique in eight near-term pregnant ewes during a normal control period and during maternal metabolic alkalosis. All measurements were made on awake, unanesthetized animals. Alkalosis, defined for this study as an arterial pH of 7.60 or greater, was produced by the oral administration of sodium bicarbonate, 3 g/kg body wt. The rise in pH thus produced was unaccompanied by significant changes in systemic arterial blood pressure and cardiac output, while maternal arterial P/sub CO$sub 2$/ rose slightly from control levels. Cotyledonary blood flow declined from a control value of 1.177 ml/min to 1.025 ml/min during alkalosis. This decline of 13 percent in cotyledonary blood flow is significant (P less than 0.02). Blood flow to the remaining uterine tissue, or noncotyledonary uterus, did not change with alkalosis, being maintained at approximately 195 ml/min. It is concluded that maternal alkalosis, unaccompanied by major changes in P /sub CO$sub 2$/ and systemic arterial pressure, causes a small increase in the resistance of the uteroplacental circulation. (auth)

• Research Organization: Univ. of Wisconsin, Madison
• NSA Number: NSA-33-029858
• OSTI ID: 4060956
• Journal Information: Am. J. Physiol., v. 228, no. 5, pp. 1497-1500, Journal Name: Am. J. Physiol., v. 228, no. 5, pp. 1497-1500; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

*BLOOD FLOW-- MEASURING METHODS
*PLACENTA-- BLOOD FLOW
*UTERUS-- BLOOD FLOW
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
CERIUM 141
CHROMIUM 51
LABELLED COMPOUNDS
METABOLIC DISEASES
MICROSPHERES
N48830* --Life Sciences--New Tracer Techniques--Other
NIOBIUM 95
PREGNANCY
SHEEP
STRONTIUM 85