TISSUE DISTRIBUTION AND CONCENTRATION OF $sup 14$C-LABELED CYCLOPHOSPHAMIDE: A PRELIMINARY REPORT
Journal Article
·
· Atompraxis (West Germany) Incorporated in Kerntechnik
OSTI ID:4060320
The tissue distribution and concentration of intravenously administered / sup 14/C-labeled cyclophosphamide were studied in 10 patients. Higher concentrations were found in tumor tissue than in normal tissue. The plasma concentration is approximately 10 times that of the cellular components of the blood. Leukemic leukocytes have approximately 50% higher concentration of cyclophosphamide than do erythrocytes. The concentration of the compound within the blood is lost rapidly. Cyclophosphamide crosses the blood-brain barrier and its concentration in the spinal fluid is higher than that of blood. (auth)
- Research Organization:
- Veterans Administration Hospital, Philadelphia
- NSA Number:
- NSA-18-017421
- OSTI ID:
- 4060320
- Journal Information:
- Atompraxis (West Germany) Incorporated in Kerntechnik, Journal Name: Atompraxis (West Germany) Incorporated in Kerntechnik Vol. Vol: 10; ISSN ATPXA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
AMIDES
AROMATIC HYDROCARBONS
BIOLOGY AND MEDICINE
BLOOD CELLS
BLOOD CIRCULATION
BLOOD PLASMA
BLOOD VESSELS
BRAIN
CARBON 14
DIFFUSION
DISTRIBUTION
ENDOXAN
ERYTHROCYTES
FLUIDS
LABELLED COMPOUNDS
LEUCOCYTES
LEUKEMIA
MAN
METABOLISM
NERVOUS SYSTEM
PHOSPHORIC ACID
QUANTITY RATIO
SPINAL CORD
TISSUES
TUMORS
VARIATIONS
AROMATIC HYDROCARBONS
BIOLOGY AND MEDICINE
BLOOD CELLS
BLOOD CIRCULATION
BLOOD PLASMA
BLOOD VESSELS
BRAIN
CARBON 14
DIFFUSION
DISTRIBUTION
ENDOXAN
ERYTHROCYTES
FLUIDS
LABELLED COMPOUNDS
LEUCOCYTES
LEUKEMIA
MAN
METABOLISM
NERVOUS SYSTEM
PHOSPHORIC ACID
QUANTITY RATIO
SPINAL CORD
TISSUES
TUMORS
VARIATIONS