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Plutonium-induced lymphadenitis in beagles

Conference ·
OSTI ID:4059991
;
Plutonium oxide particles accumulate in the tracheobronchial lymph nodes of beagles exposed by inhalation and in the popliteal lymph nodes after subcutaneous injection in the hind paws. The sequence of histopathologic changes after phagocytosis of particles included necrosis, increased numbers of macrophages, and fibroplasia. Scar tissue eventually replaced the normal architecture of the lymph nodes and sequestered the plutonium particles from surrounding parenchyma. Electron microscopy showed that plutonium particles were aggregated in phagolysosomes of macrophages. (auth)
Research Organization:
Battelle Pacific Northwest Labs., Richland, WA; Battelle Pacific Northwest Labs., Richland, Wash. (USA); USAEC Division of Biomedical and Environmental Research, Washington, D.C.
NSA Number:
NSA-33-023569
OSTI ID:
4059991
Report Number(s):
CONF-740930--
Country of Publication:
United States
Language:
English

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Related Subjects

*LYMPH NODES-- BIOLOGICAL RADIATION EFFECTS
560162* --Biomedical Sciences
Applied Studies--Radiation Effects--Radionuclide Effects--Internal Source--Animals
BEAGLES
INHALATION
N48620* --Life Sciences--Radionuclide Effects (Internal Source)--Animals
PATHOLOGICAL CHANGES
PLUTONIUM
PLUTONIUM OXIDES
SUBCUTANEOUS INJECTION