Marked suppression of thyroid function in rats with gram-negative septicemia

Journal Article · Sun Feb 01 00:00:00 EST 1976 · J. Nucl. Med., v. 17, no. 2, pp. 104-107

OSTI ID:4059311

Kan, M K; Garcia, J F; McRae, J; Chang, L T; Linfoot, J A; Perez- Mendez, V

Gram-negative septicemia was induced in rats by two daily injections of fecal mixture into the thigh, after which the thyroid function was markedly suppressed for 2 days. Iodine metabolism was studied by organ radioassay and by imaging with a multiwire proportional chamber (MWPC) at various time intervals after intravenous injection of $sup 125$I. Plasma T$sub 3$, T$sub 4$, and TSH, measured by radioimmunoassays, were suppressed, as were the T$sub 3$-resin uptakes. Fractional blood supply to the thyroid glands of the infected rats, studied by the $sup 81$Rb uptake method, was also found to be markedly reduced. Sections of the thyroid glands showed little structural change during the period of marked thyroid suppression. There was no biochemical evidence of renal failure in the septicemic rats. (auth)

• Research Organization: Univ. of California, Berkeley
• NSA Number: NSA-33-023646
• OSTI ID: 4059311
• Journal Information: J. Nucl. Med., v. 17, no. 2, pp. 104-107, Other Information: Orig. Receipt Date: 30-JUN-76
• Country of Publication: United States
• Language: English

Related Subjects

N48830* -Life Sciences-New Tracer Techniques-Other
550601* -Biomedical Sciences
Basic Studies-Medicine- Unsealed Radionuclides in Diagnostics
*SCINTISCANNING- IODINE 125
*THYROID- SCINTISCANNING
*THYROXINE- RADIOIMMUNOASSAY
*TRIIODOTHYRONINE- RADIOIMMUNOASSAY
*TSH- RADIOIMMUNOASSAY
INFECTIOUS DISEASES
RATS
RUBIDIUM 81
TRACER TECHNIQUES
UPTAKE