CHANGES OF CHOLINESTERASE IN THE BLOOD AND TISSUES OF RATS SUBJECTED TO IONIZING RADIATION

Journal Article · Fri Mar 01 00:00:00 EST 1963 · Folia Medica (Naples) (Italy)

OSTI ID:4057936

Tominz, L; Andri, L; Caprotti, M

Cholinesterase activity in blood and in liver, kidney, and brain homogenates of rats subjected to sublethal doses of ionizing radiation was studied. Male rats ( approximates 250 g) were divided into groups, of which the control group numbered 12. Another group (13 animals) was sacrificed 3 hr after total irradiation (230 kv; 12 ma; filter 1 mm Cu, 1 mm Al; total dose 600 r); a third group was sacrificed 24 hr after total irradiation. Cholinesterase activity was measured by the method of Salvini and Tominz and of Tominz and Cazzaniga; results, expressed in mu moles NaOH consumed in 1 min by 1 ml blood or 1 g tissue, were as follows for controls, 3-hr animals, and 24-hr animals: liver, 3.84 plus or minus 0.33, 4.11 plus or minus 0.19,4.13 plus or minus 0.16; kidneys, 2.06 plus or minus 0.27, 1.9 plus or minus 0.20, 1.8 plus or minus 0.09; brain, 8.7 plus or minus 1.5, 9.8 plus or minus 0.56, 9.19 plus or minus 1.2; total blood, 0.882 plus or minus 0.164, 0.884 plus or minus 0.031, 0.715 plus or minus 0.024. Thus, significant variations in tissue cholinesterase do not appear on total irradiation; on the other hand total blood activity drops by 23% at the third hr and 20% at the 24th. (BBB)

• Research Organization: Universita, Pavia, Italy
• NSA Number: NSA-18-017517
• OSTI ID: 4057936
• Journal Information: Folia Medica (Naples) (Italy), Vol. Vol: 46; Other Information: Orig. Receipt Date: 31-DEC-64
• Country of Publication: Country unknown/Code not available
• Language: Italian

Related Subjects

BIOLOGY AND MEDICINE
ANIMAL CELLS
BIOCHEMISTRY
BLOOD PLASMA
BRAIN
CHEMICAL REACTIONS
CHOLINESTERASE
ENZYMES
IRRADIATION
KIDNEYS
LETHAL DOSE
LIVER
MEASURED VALUES
NUMERICALS
PERFORMANCE
QUANTITATIVE ANALYSIS
RADIATION DOSES
RADIATION EFFECTS
RATS
REACTION KINETICS
SODIUM HYDROXIDES
STANDARDS
SUSPENSIONS
TISSUES
VARIATIONS