ELECTRON MICROSCOPIC STUDY OF EARLY CHANGES INDUCED BY FAST-NEUTRON IRRADIATION OF RABBIT LENS AND CILIARY BODY (in Japanese)
The eyes of young albino rabbits were irradiated with fast neutrons, at doses of approximates 400 rad to the right and 500 rad to the left eye. The lens (epithelial cells from the intermediate zone and equator, and young lens fibers in the equatorial cortex) and ciliary epithelial cells were investignted by electron microscopy, after removal of the eyeballs 24, 48 hr, and 4 days later, in addition, to clinical observations. Almost no clinically detectable change was seen. Mitochondria and endoplasmic reticulum of lens epithelial cells were enlarged and vacuolated, beginning 24 hr after irradiation. The enlargement of these organelles decreased by the fourth day. There was little change in the Golgi apparatus. Nucleoli of lens epithelium and young lens fibers appeared fragmerted and aggregated beginning 48 hr after neutron exposure. The change was more severe on the fourth day. Multiple vesicles were seen in the cytoplasm of the ciliary epithelium 24 and 48 hr after irradiation, and formation of abnormal gaps in intercellular space between nonpigmented and pigmented epithelium was seen four days after irradiation. Fragmentation and aggregation of nucleoli of lens epithelial cells and young lens fibers were the most conspicuous changes, and appeared to represent the fast-neutron injury in the nuclei of these cells which may later lead to formation of cataract. (BBB)
- Research Organization:
- Nagasaki Univ.
- NSA Number:
- NSA-18-017549
- OSTI ID:
- 4049570
- Journal Information:
- Nagasaki Igakkai Zasshi (Japan), Journal Name: Nagasaki Igakkai Zasshi (Japan) Vol. Vol: 37; ISSN NAGZA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Japanese
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