Direct and Abscopal Effects of X-radiation on the Thymus of the Weanling Rat

Journal Article · Sun Jan 01 04:00:00 EST 1961 · International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine

DOI:https://doi.org/10.1080/09553006114551161· OSTI ID:4045665

Law, A. W.; Mole, R. H.

The effects on the thymus of 5O r whole-body irradiation and of 50 r to the anterior half of the body, as judged by changes in weight and DNA-content, were indistinguishable. The direct effect of radiation was not altered by adrenalectomy and was recovered in five days. Using the same criteria of effect, an abscopal effect on the thymus was demonstrated after 500 r to the posterior half of the body. The abscopal effect was at its greatest 5 days after irradiation and appeared to be due solely to a reduction in food-intake, since it could be almost exactly imitated by simple restriction of food-intake to the same level as that caused by the irradiation. There was a curvilinear relation between thymic weight and body-weight. Finally, adrenalectomy and food restriction altered this relation in opposite directions.

• Research Organization: Medical Research Council Radiobiological Research Unit, Harwell, Berks, Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-15-022037
• OSTI ID: 4045665
• Journal Information: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Journal Name: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Journal Issue: 3 Vol. 3; ISSN 0020-7616
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADRENAL GLANDS
BIOLOGY AND MEDICINE
DIET
FOOD
GLANDS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RATS
RECOVERY
SURGERY
THYMUS
WEIGHT