STUDIES OF FOETAL ENVIRONMENT. EXPERIMENTAL PRODUCTION OF MALFORMATION BY CHANGING FOETAL ENVIRONMENT. II. ABNORMAL DEVELOPMENT DUE TO RADIATION. I. X-RAY IRRADIATION RELATION BETWEEN DOSE AND DEVELOPMENTAL ABNORMALITIES

Journal Article · Wed Jan 01 04:00:00 EST 1958 · Kankyo Igaku Kenkyujo Nempo

OSTI ID:4045541

Murakami, U; Kameyama, Y

Pregnant mice were irradiated with 150, 100, 50, or 25 r of x rays on the 8th day of gestation. The incidence of developmental abnormalities and the intensity and localization of malformations in the CNS usually paralleled the dosage. However, the type and degree of embryonic changes were quite different in each group. Embryos receiving more than 100 r had complex abnormalities involving all germ layers-a typical reaction to x irradiation. Irradiation with less than 100 r caused simple CNS abnormalities, but no mesodermal maiformation. It is concluded that different doses cause different types and degrees of malformation when applied to developing embryos of the same age. (Abstr. Japan Med., 1: No. 2, 1960)

• Research Organization: Nagoya Univ., Japan
• NSA Number: NSA-15-022049
• OSTI ID: 4045541
• Journal Information: Kankyo Igaku Kenkyujo Nempo, Journal Name: Kankyo Igaku Kenkyujo Nempo Vol. Vol: 9
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
EMBRYOS
FETUSES
MALFORMATIONS
MICE
NERVOUS SYSTEM
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
X RADIATION