AN UNIDENTIFIED I$sup 131$ CONTAMINANT OF RADIOIODIDE PREPARATIONS
>A non-iodide I/sup 1//sup 3//sup 1/ component was observed in a number of samples of radioiodide. This component, referred to as U, is biologically and chemically distinguishable from radioiodide. It resembles closely an I/sup 1// sup 3//sup 1/ component previously encountered in subcellular preparations incubated with radioiodide. U, which appears to be an oxidized form of inorganic iodine, is acid labile and is not as well utilized by thyroid tissue as is radioiodide. Formation of U in radioiodide preparations can be prevented by the presence of reducing agents such as sulfite, cysteine, or 1 methyl2- mercaptoimidazole. (auth)
- Research Organization:
- Univ. of Texas, Dallas
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-022328
- OSTI ID:
- 4043934
- Journal Information:
- Endocrinology (U.S.), Journal Name: Endocrinology (U.S.) Vol. Vol: 69; ISSN ENDOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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