Use of lithium as an adjunct to radioiodine therapy of thyroid carcinoma

Journal Article · Thu Jan 01 04:00:00 EST 1976 · J. Clin. Endocrinol. Metab., v. 42, no. 1, pp. 105-111

DOI:https://doi.org/10.1210/jcem-42-1-105· OSTI ID:4036544

Gershengorn, M C; Izumi, M; Robbins, J

The effect of lithium on iodine kinetics after oral $sup 131$I-iodide was studied in an athyreotic patient with follicular thyroid carcinoma. Lithium decreased the disappearance rate of $sup 131$I from the whole body and from a tumor mass in the patient's thigh from control values of 0.126/day and 0.122/day to 0.090/day and 0.049/day, respectively, while having only a minimal effect on the rate of $sup 131$I disappearance from blood. The increased tumor $sup 131$I retention would be expected to increase the therapeutic:toxic ratio of $sup 131$I. However, a subsequent therapeutic dose of $sup 131$I-iodide given with lithium was accompanied by an unanticipated increase in blood $sup 131$I and, therefore, in whole body radiation, resulting in significant bone marrow depression. Although lithium may be a useful adjunct in $sup 131$I therapy of functional thyroid carcinoma, it must be used cautiously in future studies. (auth)

• Research Organization: National Inst. of Health, Bethesda, MD
• Sponsoring Organization: USDOE
• NSA Number: NSA-33-026224
• OSTI ID: 4036544
• Journal Information: J. Clin. Endocrinol. Metab., v. 42, no. 1, pp. 105-111, Journal Name: J. Clin. Endocrinol. Metab., v. 42, no. 1, pp. 105-111; ISSN JCEMA
• Country of Publication: United States
• Language: English

Related Subjects

*BONE MARROW-- BIOLOGICAL RADIATION EFFECTS
*LITHIUM-- RADIOSENSITIVITY EFFECTS
*RADIOTHERAPY-- SIDE EFFECTS
560151* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Man
CARCINOMAS
INTERNAL IRRADIATION
IODINE 131
N48510* --Life Sciences--Radiation Effects on Animals--Man
PATIENTS
THYROID