Chemistry of /sup 99m/Tc tracers. II. In vitro conversion of tagged HEDP and pyrophosphate (bone-seekers) into gluconate (renal agent). Effects of Ca and Fe(II) on in vivo distribution

Journal Article · Sun Feb 29 23:00:00 EST 1976 · J. Nucl. Med., v. 17, no. 3, pp. 208-211

OSTI ID:4036279

McRae, J; Hambright, P; Valk, P; Bearden, A J

Sodium gluconate transforms the bone-seekers $sup 99$/sup m/Tc-HEDP and $sup 99$/sup m/Tc-pyrophosphate into the renal agent $sup 99$/sup m/Tc-gluconate. In these in vitro processes, pyrophosphate is displaced faster than HEDP, while the HEDP reaction is accelerated by calcium ions. The in vivo distributions of these bone and kidney agents are altered by the prior local injection of calcium or iron(II). These transformation and translocation phenomena are explained in terms of the mechanistic behavior of Tc(IV) complexes. (auth)

• Research Organization: Univ. of California, Berkeley
• NSA Number: NSA-33-029852
• OSTI ID: 4036279
• Journal Information: J. Nucl. Med., v. 17, no. 3, pp. 208-211, Journal Name: J. Nucl. Med., v. 17, no. 3, pp. 208-211; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

*BONE SEEKERS-- METABOLISM
*CALCIUM IONS-- BIOLOGICAL EFFECTS
*IRON IONS-- BIOLOGICAL EFFECTS
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
COMPLEXES
ISOMERIC NUCLEI
N48830* --Life Sciences--New Tracer Techniques--Other
PHOSPHONATES
PYROPHOSPHATES
SODIUM COMPOUNDS
TECHNETIUM 99
TISSUE DISTRIBUTION